Position: Senior Staff Scientist
Department: Human Genetics, Wellcome Sanger Institute
Keywords: T cells, mucosal immunology, Inflammatory Bowel Disease, CRISPR/Cas9
I am an immunologist interested in finding out how our DNA affect our likelihood of developing certain diseases.
I originally came from Rio de Janeiro, Brazil and after my PhD I moved to the UK to develop a project investigating the interaction of bone-marrow cells and the lung mucosa in the context of Asthma. During this time, I developed a great curiosity towards a subtype of immune cells, namely T cells. These cells are central for the immune response and dysregulation of their function have serious consequences for human health.
After a career break to raise my young family, I was granted a return-to-science fellowship at the Wellcome Sanger Institute in 2018, and joined Dr Carl Anderson team in the Human Genetics Department. Our group and others have used genome-wide association studies (GWAS) to identify over 240 regions (or loci) of the human genome that increase susceptibility to the development of inflammatory bowel disease (IBD; which includes Crohn’s disease and Ulcerative Colitis). I am currently undertaking studies to investigate how the genetic variation in these loci influence human immunological regulation and as a consequence how they contribute to IBD development. To do that, I am editing the genome of primary T cells using CRISPR-Cas9 technology to evaluate cell function and transcriptional consequences of these edits. I am also using powerful tools like genome-wide CRISPR screens to better understand the differences in patient response to drugs that are currently being use in clinic to treat IBD patients.
Get in touch: cjb [at] sanger.ac.uk; twitter @carlajonesbio