Lorena Boquete Vilarino

lorenabv@mrc-lmb.cam.ac.uk

Position

Postdoctoral Researcher

Affiliation

MRC Laboratory of Molecular Biology

Keywords

Immuno-oncology, Dendritic Cells, Immunity in Cancer, Cancer Microenvironment

Cancer cells can be detected and eliminated by our immune system, but this function is commonly disrupted in tumours. I am interested in understanding this disfunction and how we can help our immune system fight cancer.

The human immune system is composed of many cell types with different roles. I am interested in dendritic cells (DC), which uptake molecules both from pathogens and from our own cells. DC communicate with other immune cells and stimulate them to eliminate threats (leading to an immune response) or to ignore our own cells (leading to immune tolerance). Cancer cells usually have abnormal molecules (antigens, e.g. mutated proteins) on their surface and can express ‘danger signals’ – molecules located out of place, such as DNA outside of the nucleus. These abnormal antigens and danger signals should activate DC, leading them to signal for an immune response against cancer cells. However, cancer cells evolve mechanisms to avoid DC response. I am working to identify how danger signals are expressed, and how to avoid immune tolerance of cancer. I am using an in vitro model of cancer cell-dendritic cell communication, CRISPR/Cas9 screening and confocal microscopy to do this.

I am fascinated by how cells communicate in health and disease. During my PhD at the University of Exeter I investigated cell communication between cancer cells and surrounding tissue. I also have an interest in building cell models of disease – I have worked on human stem cell reprogramming from healthy and diseased donors and their differentiation to other cell types of interest.

Add your profile to the site

If you are an early career cis and trans woman researcher from the University of Cambridge or affiliated institutes, you can add your profile to the site. Fill in this form and we will be in touch.

For anything else, don’t hesitate to reach out by emailing us stepwide.cam@gmail.com.

This website

This website showcases the profiles of early career cis and trans women researchers from the University of Cambridge, UK, and affiliated institutions. It originated as part of StepWide, a leadership programme that aims to support the next generation of female researchers.

We hope that by making the expertise and stories of early career women researchers more visible (and searchable!), will highlight how much they contribute to the research that is done in the University and affiliated institutions.

Who is it for

This website is designed for a wide audience, be it other researchers looking for particular expertise for a collaboration; the media looking for experts; those that are simply curious about what type of research is done in Cambridge, or those trying to get a clearer idea of what a ‘typical’ woman researcher in this years old institution does (there is no ‘typical’!).

The StepWide programme

StepWide was designed by 3 postdocs at Cambridge (see below for more on Marta, Laura and Cemre). It aims to support female postdoctoral researchers at the University of Cambridge, UK, from any discipline, who feel that taking a step into leadership is not for them. The programme is designed to suit both early and more senior postdocs, providing them with the skills to challenge the current ideas of what a leader is, learn how to raise their public profiles, as well as a close and supportive network of peer-to-peer female postdocs.

StepWide ran for the first time in 2019/2021, and we are currently running a new series of workshops in 2022/2023. We will post updates here when applications open for its next run.

Laura, Marta and Cemre (left to right on the photo) met at The Postdocs of Cambridge (PdOC) Society, at the University of Cambridge, UK. When the Researcher Development (RD) Pitch Competition was announced in late 2018, they felt this provided the ideal opportunity to work together to develop a leadership programme for women postdocs. They saw a gap in the current leadership RD provision, with a lack of opportunities that challenge current leadership views. Their proposal was successful and obtained funding for a one year pilot, giving rise to the StepWide programme.

Laura Fachal is a Senior Staff Scientist at Wellcome Sanger Institute. She earned her BS in Veterinary, MSc in Biotechnology and PhD from University of Santiago de Compostela, Spain. She completed her postdoc at the Centre for Cancer Genetic Epidemiology, University of Cambridge. She is also a Research Associate at Lucy Cavendish College.

Marta Costa is a Senior Research Associate at the Department of Zoology. She did her undergrad in Biology in Lisbon, Portugal, followed by an MSc in Neuroscience at UCL in London. She then moved to Cambridge for her PhD, followed by a postdoc. She is also a Research Associate at Lucy Cavendish College.

Cemre Ustunkaya was a Post-doctoral Research Associate at the McDonald Institute for Archaeological Research. She earned her BSc in Biological Science, followed by an MSc in Archaeometry at Middle East Technical University, Turkey. She later moved to Australia for her PhD in Archaeology at The University of Queensland. She is also a postdoc affiliate at Newnham College.

Thanks and funding

StepWide was funded by the Researcher Development Pitch Competition which included support from the Researcher Development Programme, The Postdocs of Cambridge (PdOC) Society, the Postdoc Academy, the Postdoc Chairs’ Network and the Careers Service at the University of Cambridge. We are very thankful for their support. We would also like to thank Alba Gómez for her expert support with the first version of the website, and to Arian Jamasb for redesigning and implementing the newest version of this website. Finally, we thank Natacha Wilson and Rebecca Nestor for the advice and support they provided for the development of the workshops.